Hypercalciuria and recurrent urinary stone formation despite successful surgery for primary hyperparathyroidism.

Re-explorative Parathyroid Surgery for Persistent and Recurrent Primary Hyperparathyroidism

Primary hyperparathyroidism (HPT) is treated by parathyroidectomy. Excision of abnormal parathyroid tissue is curative in the majority of cases. Postoperative persistent or recurrent HPT has been reported up to 30%. The purpose of this study was to evaluate the role of imaging techniques and determine the efficacy of reexplorative surgery. A total of 306 patients underwent parathyroidectomy bet...

Does urinary stone composition and morphology help for prediction of primary hyperparathyroidism?

BACKGROUND Primary hyperparathyroidism (HPT) is a common cause of urolithiasis. Only a few data are available on stone composition and morphology in HPT patients. METHODS We compared the composition and morphology of stones from 264 HPT patients (143 males and 121 females) and 24 567 non-HPT stone formers (16 918 males and 7649 females) including a subgroup of 1356 patients with idiopathic hy...

Recurrent Acute Pancreatitis: A Diagnostic Clue to Primary Hyperparathyroidism

Urinary pH and stone formation.

The formation of various types of kidney stones is strongly influenced by urinary pH. An alkaline pH favors the crystallization of calcium- and phosphate-containing stones, whereas and acidic urine pH promotes uric acid or cystine stones. The activity of many transport processes involved in calcium, citrate and phosphate handling are sensitive to changes in systemic or local pH as shown for sev...

Persistent or recurrent primary hyperparathyroidism.

More than 95% of patients with Primary Hyperparathyroidism (PHPT) are treated successfully at the initial operation when the operation is done by an experienced surgeon, but the success rate is considerably lower when done by an unexperienced surgeon. The approach to patients with persistent and recurrent PHPT is to confirm the diagnosis and to use precise localization procedures done by expert...